­
­
­
­

Inventi Impact: Med Chem

Articles

  • Inventi:pmc/32011/20
    Indole-3-carbaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and Antibacterial Activities
    Research 2020 : July - September
    Fernando Carrasco, Wilfredo Hernandez, Oscar Chupayo, Celedonio M ´Alvarez, Sandra Oramas-Royo, Evgenia Spodine, Carmen Tamariz-Angeles, Percy Olivera-Gonzales, Juan Z D´avalos

    Four indole-3-carbaldehyde semicarbazone derivatives, 2-((5-bromo-1H-indol-3-yl)methylene)hydrazinecarboxamide (1), 2-((5-\nchloro-1H-indol-3-yl)methylene)hydrazinecarboxamide (2), 2-((5-methoxy-1H-indol-3-yl)methylene)hydrazinecarboxamide (3), and\n2-((4-nitro-1H-indol-3-yl)methylene)hydrazinecarboxamide (4) were synthesized and characterized by ESI-MS and spectroscopic (FTIR,\n1HNMR, and 13C NMR) techniques.The two-dimensionalNMR(in acetone-d6) spectral data revealed that the molecules 1 and 2 in\nsolution are in the cisE isomeric form. This evidence is supported by DFTcalculations at the B3LYP/6-311++G(d,p) level of theory where\nit was shown that the corresponding most stable conformers of the synthesized compounds have a cisE geometrical configuration, in\nboth the gas and liquid (acetone and DMSO) phases.Thein vitro antibacterial activity of compounds 1â??4 was determined against Grampositive\n(Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria.\nAmong all the tested semicarbazones, 1 and 2 exhibited similar inhibitory activities against Staphylococcus aureus.................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Carrasco, Fernando, et al. \"Indole-3-carbaldehyde Semicarbazone Derivatives: Synthesis,\nCharacterization, and Antibacterial Activities.\" Journal of Chemistry 2020 (2020).\nhttps://doi.org/10.1155/2020/7157281\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
    Download Full Text